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The small amount of increased oxygen that is needed by the cells to improve their function does not necessarily require new blood vessel formation to be accomplished because with HBOT free oxygen molecules are dissolved directly into the cerebrospinal fluid Therefore these cells are no longer dependent on increased oxygen delivery from increased blood vessel formation that secondarily delivers a greater oxygen load because it carries more hemoglobin.At times it may actually be the sudden removal of higher than normal oxygen concentrations that the body has adapted to rather than the higher levels of oxygen itself that may stimulate angioneogenesis There are reports that the new vessel formation in the retinas of premature infants who were on high doses of oxygen was stimulated by the rapid removal of oxygen and not from the oxygen itself.The literature states that in order to kill viruses 100% oxygen at 2.7 ATA or above is required.

Efrain Olszewer has pre- and post-angiograms documenting collateral circulation beginning as early as ten to twenty hours after initiating hyperbaric therapy for cerebral vascular disease and peripheral arteriosclerosis at pressures lower than 1.3 ATA It is known that one of the problems children with autism have is decreased blood flow to the brain (cerebral hypoperfusion).

Therefore is has been speculated that angioneogenesis is the way that HBOT helps autism However, though angioneogenesis may be one mechanism by which children with autism are helped by HBOT, angioneogenesis may not be the primary mechanism by which HBOT works The amount of cerebral hypoperfusion in autistics compared to controls is about 8%, so a small increase in oxygen delivery may be all that is needed to overcome this deficit and show clinical benefit.

Children with autism have difficulty handling viral infections, most likely due to immune dysfunction.

It has been postulated many times that children with autism have a chronic low grade viral gastroenteritis and viral encephalitits. I speculate that one of the primary reasons HBOT works so well for so many children whose abnormal stools improve once they start HBOT is because the chronic, low-grade, smoldering live viral load harbored in the intestinal mucosa (Wakefield/Krigsman hypothesis) does poorly when surrounded by higher oxygen concentrations.

, not only due to the competing mechanisms of vasodilation and vasoconstriction, but also due to decreasing the inflammation that secondarily constricts blood vessel lumens in a closed spac.

Because inflammation is accompanied by swelling, tissue expansion or compression will occur.

You will hear many terms used interchangeably by lay people and professionals alike: hyperbaric oxygen therapy (HBOT), mild hyperbaric oxygen therapy (m HBOT), hyperbaric therapy (HBT), hyperbaric oxygen (HBO), hyperbaric air therapy (HBAT), hyperbaric enriched air therapy (HBEAT), etc. There is also no doubt that it works well at low pressures with varying degrees of oxygen concentrations as well as at varying degrees of high pressures with 100% oxygen.

However, the most common way the term is used by the autism community is to just say "HBOT". Kartzinel, and the tremendous number of children that have been treated by physicians such as Dr. The reason I recommend HBOT for all my patients is because there is scientific evidence that pressure, independent of the concentration of oxygen, decreases inflammation and that any concentration of oxygen under any increased amount of pressure will allow more oxygen to dissolve into the extracellular fluids of the body: plasma, lymph, cerebrospinal fluid, and interstitial fluid.

Recent studies have demonstrated that children with autism frequently have neuro-inflammatory and gastrointestinal inflammatory conditions occurring.

Multiple studies demonstrate the beneficial effect of hyperbaric oxygen therapy in inflammatory conditions.

A recent study documented impaired production and abnormal ratios of porphyrins in children with autism.

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